The Bolts plan to deactivate front seven starters Luis Castillo (ankle) and Shawne Merriman (foot), in addition to run-stopping S Eric Weddle (knee). San Diego is friendly to opposing running backs in the first place, so it will be interesting to see if Jennings or Harrison can capitalize. My Pick Chargers 4:15PM ET Games Dallas at NY GiantsBrandon Jacobs' 27 yards on 11 carries in week 12 against a Denver team that had been gashed for 100 by opposing RBs in each of its last five games couldn't have been more disappointing. While Jacobs didn't look good himself running East-West instead of North-South all too often the Giants clearly have lost their identity.Despite Eli Manning's accuracy woes caused by a foot injury, Jacobs has seen 20 carries just once in the last six games. Danny Ware's (concussion) absence and Ahmad Bradshaw's injuries to both ankles would seemingly set Jacobs up for 20 touches this Sunday, but that's up to the Giants, who seem to think that they are a passing team Dallas also ranks No 9 against the run Use Jacobs at your own risk. Manning, coming off a Thanksgiving effort in which he had 28 yards at half and looked positively brutal, now faces a Cowboys pass defense that's made major strides since a slow start. 
Assisted by the NFL's seventh-best pass rush, Dallas has allowed three passing TDs in its last four games. Bench Manning unless you're in a two-QB league.The Cowboys (i.e. Orlando Scandrick) set the table for Mario Manningham's week 2 "breakout" (10-150-1). Scandrick, however, has been benched and replaced by steady RCB Mike Jenkins Avoid Manningham and Hakeem Nicks Steve Smith is the only consistent Giants wideout. Kevin Boss, coming off a 22-yard game, is another routinely weak play.

The absence of Giants top safety Michael Johnson (groin) hurts badly against Dallas' big-play offense C.C. Brown, who's been a coverage liability in previous spot starts this year, will be forced to start against a Cowboys team that's produced the second most 20 yard completions in the league.Tony Romo is coming off one of his better games of 2009 (309 yards, two TDs) against a tough Oakland pass defense, and should be used confidently in this matchup Jason Witten and Miles Austin also get boosts Roy Williams is a non-factor until he picks up his play. The demotions of DE Osi Umenyora and DT Fred Robbins don't make a difference in terms of matchups, mostly because new Giants starters Mathias Kiwanuka and Chris Canty could easily prove better options.Marion Barber's week 12 105-total yard effort was disappointing considering the opponent (Oakland), and Felix Jones and Tashard Choice both saw action. This matchup isn't ideal for Barber, but he's still a viable low-end RB2 because he will get goal-line carries if Dallas gets close enough. He's also playing well, averaging over 4.2 YPC in each of his last four games. My Pick Cowboys San Francisco at Seattle Justin Forsett has too many factors working against him to be a viable fantasy option this week. Julius Jones is back to retake his starting job and red-zone work, the 49ers are fifth against the run, and Forsett strained his quadriceps on the practice field Friday.
Forsett might still play on some third downs and remains Seattle's best option in the backfield when healthy, but there's not much to like about him in Week 13.Season-long bust T.J. Houshmandzadeh has a good matchup, but is hard to get excited about when he's averaged three catches for 25 yards in his last two games. John Carlson shouldn't have to block often because the 49ers have a weak pass rush and is a low-end TE1. The best way to attack San Francisco's defense is through the air. Thus, thematch-up favors a Seahawks offense that has gradually evolved into a pass-heavy unit and will remain so with its best running back in danger of sitting out.The Niners rank 28th against the pass, and the Qwest Field conditions (10 percent winds, 10 percent chance of rain) are of little concern Matt Hasselbeck is a high-quality start in two-QB leagues.